With a bit more data from strace I get the following picture:
...
[pid 6555] stat("/dev/nvidiactl", {st_dev=makedev(0, 6), st_ino=487, st_mode=S_IFCHR|0666, st_nlink=1, st_uid=0, st_gid=0, st_blksize=4096, st_blocks=0, st_rdev=makedev(195, 255), st_atime=2017-11-03T12:14:40+0100.694587974, st_mtime=2017-11-03T12:14:40+0100.694587974, st_ctime=2017-11-03T12:14:40+0100.694587974}) = 0
[pid 6555] --- SIGSYS {si_signo=SIGSYS, si_code=SYS_SECCOMP, si_errno=ENOENT, si_call_addr=0x7fc59eaf002d, si_syscall=__NR_open, si_arch=AUDIT_ARCH_X86_64} ---
[pid 6555] stat("/dev/nvidiactl", 0x7ffc10066500) = -1 EPERM (Operation not permitted)
[pid 6555] mknod("/dev/nvidiactl", S_IFCHR|0666, makedev(195, 255)) = ?
What is odd is that the stat("/dev/nvidiactl") works and then stops working.